Top-US-Grossing Sci-Fi Titles Released in 2000

Scientist Sherman Klump's inventions, his upcoming marriage to his pretty colleague Denise Gaines and his reputation are threatened by his evil clone Buddy Love.
Buddy becomes a sentient being

When the leader of a team of scientists volunteers to be the test subject for their experiment in human invisibility, he slowly unravels and turns against them, with horrific consequences.

Imagine the power of not being seen, falling in the wrong hands
An F.B.I. Agent persuades a social worker, who is adept with a new experimental technology, to enter the mind of a comatose serial killer in order to learn where he has hidden his latest kidnap victim.
There is a girl that is missing.

These girls are kidnapped, tortured, and killed. He keeps the girls in this thing. After 40 hours the water starts rising.
When the first manned mission to Mars meets with a catastrophic and mysterious disaster after reporting an unidentified structure, a rescue mission is launched to investigate the tragedy and bring back any survivors.
this is a truely anomolous formation. We are trying not to go nuts up here. 
Mars base camp transmission.
An accidental cross-time radio link connects father and son across 30 years. The son tries to save his father's life, but then must fix the consequences.
Once in a decade massive solar storms disturb our communications.
And result into unexplained phenomena.
A commercial transport ship and its crew are marooned on a planet full of bloodthirsty creatures that only come out to feast at night. But then, they learn that a month-long eclipse is about to occur.
On this planet the things come out when the light is out. 
A ship crashes on a planet. 
[11] 6th Day
Futuristic action about a man who meets a clone of himself and stumbles into a grand conspiracy about clones taking over the world.
through technology your life can be stolen
cloning technology
Astronauts, and their robotic dog AMEE (Autonomous Mapping Evaluation and Evasion), search for solutions to save a dying Earth by searching on Mars, only to have the mission go terribly awry.
Supernova chronicles the search and rescue patrol of a medical ship in deep space in the early 22nd century and its six-member crew which includes a captain and pilot, a co-pilot, a medical officer, a medical technician, a search and rescue.
AI chess hologram.
They answered a critical SOS signal.
Three different stories involving digital creatures collide together.
Digimon the Movie
A digi virus will infect the internet
Digi creatures
this journey can only be experienced on the big screen.
A human-looking alien from a highly advanced but emotionless all-male society is sent to Earth to impregnate a woman.
A hologram of a woman.
In an undefined future having big insurance corporations, Thomas is a thirty-three years old retired man having agoraphobia for eight years. He uses cyber-sex for sexual self-satisfaction and never leaves his place or receives any visit.